Fmoc-Asn(Trt)-Ser(psiMe,Mepro)-OH

• CAS: 920519-33-1
• Catalog Number: ACM920519331-1
• Category: Amino Acids
• Molecular Weight: 723.81
• Description: This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Asn-Ser dipeptide motif. It consists of a dipeptide in which the serine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The serine residue is regenerated during the normal TFA-mediated cleavage reaction.
• Synonyms: Fmoc-Asn(Trt)-Ser(psiMe,Mepro)-OH
• InChI: 1S/C44H41N3O7/c1-43(2)47(38(28-54-43)41(50)51)40(49)37(45-42(52)53-27-36-34-24-14-12-22-32(34)33-23-13-15-25-35(33)36)26-39(48)46-44(29-16-6-3-7-17-29,30-18-8-4-9-19-30)31-20-10-5-11-21-31/h3-25,36-38H,26-28H2,1-2H3,(H,45,52)(H,46,48)(H,50,51)
• InChI Key: CURRWEJPHUVJFC-UHFFFAOYSA-N
• Application: Peptide synthesis.
• Assay: ≥95% (TLC); ≥97.0% (HPLC)
• Form: powder
• Functional Group: hydroxyl
• Quality Level: 200
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-8℃