Flufenamic acid

• CAS: 530-78-9
• Catalog Number: ACM530789
• Category: Inhibitors
• Molecular Weight: 281.23
• Molecular Formula: C₁₄H₁₀F₃NO₂
• Description: Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
• Synonyms: inf1837;Lanceat;Meralen;N-((m-Trifluoromethyl)phenyl)-2-aminobenzoic acid;N-(alpha,alpha,alpha-Trifluoro-m-tolyl)anthranilate;n-(alpha,alpha,alpha-trifluoro-m-tolyl)-anthranilicaci;n-(m-trifluoromethylphenyl)-2-aminobenzoicacid;Nichisedan
• Melting Point: 132-135°C(lit.)
• Hazard Statements: Xn
• Safety Description: 26
• Supplemental Hazard Statements: H302-H335-H301-H315-H319
• Symbol: GHS07,GHS06

Synthetic Use

Upstream Synthesis Route 1

• 2765-91-5

• 530-78-9

Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 5, p. 1464 - 1468
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 5, p. 2311 - 2323
[3] Patent: US9271961, 2016, B2, . Location in patent: Page/Page column 58; 59
[4] Patent: US5462952, 1995, A,

Upstream Synthesis Route 2

• 98-16-8
• 118-91-2

• 530-78-9

Reference: [1] Tetrahedron Letters, 1997, vol. 38, # 29, p. 5107 - 5110
[2] Synthetic Communications, 1989, vol. 19, # 11-12, p. 2077 - 2080
[3] Journal of the American Chemical Society, 1960, vol. 82, p. 1600 - 1607

Downstream Synthesis Route 1

• 530-78-9

• 92-30-8

Reference: [1] Journal of the American Chemical Society, 1960, vol. 82, p. 1600 - 1607

Downstream Synthesis Route 2

• 627-42-9
• 530-78-9

• 64352-83-6

Reference: [1]Arzneimittel-Forschung/Drug Research,1977,vol. 27,p. 1300 - 1312

Downstream Synthesis Route 3

• 628-34-2
• 530-78-9

• 64352-82-5

Reference: [1]Arzneimittel-Forschung/Drug Research,1977,vol. 27,p. 1300 - 1312

Downstream Synthesis Route 4

• 625-56-9
• 530-78-9

• 29098-19-9

Reference: [1]Farmaco, Edizione Scientifica,1975,vol. 30,p. 276 - 286

* For details of the synthesis route, please refer to the original source to ensure accuracy.