F13714 fumarate

• CAS: 208109-39-1
• Catalog Number: ACM208109391
• Category: Agonists
• Molecular Weight: 538.98
• Molecular Formula: C25H29ClF2N4O5
• Description: F13714 is a Serotonin 5-HT1A Receptor Agonist. F13714 shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress. F13714 has a high affinity (0.1 nM) and selectivity for 5-HT(1A) receptors. In vitro (18)F-F13714 binding in rats was consistent with the known 5-HT(1A) receptors distribution (hippocampus and cortical areas) and was particularly high in the dorsal raphe. In vitro binding of (18)F-F13714 was blocked in a dose-dependent fashion by WAY100635, the prototypical 5-HT(1A) antagonist, and by the endogenous agonist, serotonin (5-HT). Addition of Gpp(NH)p also inhibited in vitro (18)F-F13714 binding, consistent with a preferential binding of the compound to G-protein-coupled receptors. Ex vivo tissue measurements in rat revealed an absence of brain radioactive metabolites.
• Synonyms: F13714 fumarate; F13714; F-13714; F 13714; F 14679; F-14679; F14679
• IUPAC Name: 3-chloro-4-fluorophenyl-(4-fluoro-4-(((5-methyl-6-methylaminopyridin-2-ylmethyl)amino)methyl)piperidin-1-yl)methanone fumarate
• Canonical SMILES: O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CNCC3=NC(NC)=C(C)C=C3)(F)CC2.O=C(O)/C=C/C(O)=O
• InChI: InChI=1S/C21H25ClF2N4O.C4H4O4/c1-14-3-5-16(27-19(14)25-2)12-26-13-21(24)7-9-28(10-8-21)20(29)15-4-6-18(23)17(22)11-15;5-3(6)1-2-4(7)8/h3-6,11,26H,7-10,12-13H2,1-2H3,(H,25,27);1-2H,(H,5,6)(H,7,8)/b;2-1+
• InChI Key: HZJWIYFEDQNBEU-WLHGVMLRSA-N
• Solubility: To be determined
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Alternative CAS: 208109-39-1 (fumarate); 208109-38-0 (free base)
• Drug Formulation: To be determined
• Elemental Analysis: C, 55.71; H, 5.42; Cl, 6.58; F, 7.05; N, 10.40; O, 14.84
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).