CAS
1786438-30-9 Purity
>98.5%
1786438-30-9 Purity
>98.5%
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Eragidomide
CAS
1860875-51-9
Catalog Number
ACM-MG-1860875519
Category
Molecular Glues
Molecular Weight
461.85
Molecular Formula
C22H18ClF2N3O4
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Specification
Description
Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation.
Synonyms
CC-90009
IUPAC Name
2-(4-chlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2,2-difluoroacetamide
SMILES
O=C(NCC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2)=O)C=C1)C(F)(F)C4=CC=C(Cl)C=C4
InChI
InChI=1S/C22H18ClF2N3O4/c23-15-4-2-14(3-5-15)22(24,25)21(32)26-10-12-1-6-16-13(9-12)11-28(20(16)31)17-7-8-18(29)27-19(17)30/h1-6,9,17H,7-8,10-11H2,(H,26,32)(H,27,29,30)
InChI Key
PWBHUSLMHZLGRN-UHFFFAOYSA-N
Appearance
Off-white to light yellow solid
Shipping
Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions
Store at 4 °C
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