EN450

• CAS: 793719-01-4
• Catalog Number: ACM-MG-793719014
• Category: Molecular Glues
• Molecular Weight: 288.75
• Molecular Formula: C11H13ClN2O3S
• Description: EN450 is a cysteine-responsive covalent molecular gel degrader of targeted NF-κB with antiproliferative and potentially anticancer activity, which acts through a dependence on Cullin E3 ligase and protease, and can be used to study leukemia.
• Synonyms: N-(2-Chloro-5-(N,N-dimethylsulfamoyl)phenyl)acrylamide
• IUPAC Name: N-[2-chloro-5-(dimethylsulfamoyl)phenyl]prop-2-enamide
• SMILES: O=C(C=C)NC1=CC(=CC=C1Cl)S(=O)(=O)N(C)C
• InChI: InChI=1S/C11H13ClN2O3S/c1-4-11(15)13-10-7-8(5-6-9(10)12)18(16,17)14(2)3/h4-7H,1H2,2-3H3,(H,13,15)
• InChI Key: OXFXDOLAQBMOPH-UHFFFAOYSA-N
• Density: 1.364 g/cm3 at 20 ℃ (Predicted)
• Solubility: DMSO: 60 mg/mL (207.79 mM), Sonication is recommended.
• Shipping: Shipping with blue ice.
• Storage Conditions: Store at low temperature