EN171

• CAS: 2191110-79-7
• Catalog Number: ACM-MG-2191110797
• Category: Molecular Glues
• Molecular Weight: 270.37
• Molecular Formula: C17H22N2O
• Description: EN171, a covalent ligand, selectively binds to C38 and C96 on 14-3-3, intensifying 14-3-3's interactions with ERα, YAP, and TAZ. This action impairs both estrogen receptor and Hippo pathway transcriptional activities. Beyond serving as a molecular glue to augment native protein interactions, EN171 also functions as a covalent recruiter for 14-3-3 in heterobifunctional molecules. This facilitates the sequestration of nuclear neo-substrates, such as BRD4 and BLC6, into the cytosol.
• Synonyms: 1-{7-benzyl-2,7-diazaspiro[4.4]nonan-2-yl}prop-2-en-1-one
• IUPAC Name: 1-(7-benzyl-2,7-diazaspiro[4.4]nonan-2-yl)prop-2-en-1-one
• SMILES: C=CC(=O)N1CCC2(C1)CCN(C2)CC3=CC=CC=C3
• InChI: InChI=1S/C17H22N2O/c1-2-16(20)19-11-9-17(14-19)8-10-18(13-17)12-15-6-4-3-5-7-15/h2-7H,1,8-14H2
• InChI Key: VKQVCQHCQMFBNJ-UHFFFAOYSA-N
• Shipping: Shipping with blue ice.
• Storage Conditions: Powder: Store at -20 °C for 3 years; In solvent: -80 °C for 1 year