Doxorubicin hydrochloride

• CAS: 25316-40-9
• Catalog Number: ACM25316409-1
• Category: Inhibitors
• Molecular Formula: C₂₇H₃₀ClNO₁₁
• Description: Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy.

Synthetic Use

Upstream Synthesis Route 1

• 29742-67-4

• 25316-40-9

Reference: [1] Carbohydrate Research, 1988, vol. 184, p. 231 - 235

Upstream Synthesis Route 2

• 23541-50-6

• 25316-40-9

Reference: [1] Carbohydrate Research, 1988, vol. 184, p. 231 - 235

Downstream Synthesis Route 1

• 108-30-5
• 25316-40-9

• 123106-18-3

Reference: [1]Synthetic Communications,2002,vol. 32,p. 1961 - 1975

* For details of the synthesis route, please refer to the original source to ensure accuracy.