Dihydromyricetin

• CAS: 27200-12-0
• Catalog Number: ACM27200120
• Category: Inhibitors
• Molecular Weight: 320.25
• Molecular Formula: C15H12O8
• Description: Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 22 μM.
• Synonyms: (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
• IUPAC Name: (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
• SMILES: C1=C(C=C(C(=C1O)O)O)[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O
• InChI: InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
• InChI Key: KJXSIXMJHKAJOD-LSDHHAIUSA-N
• Boiling Point: 780.7±60.0 °C
• Melting Point: 239-241 °C
• Density: 1.808±0.06 g/ml
• Appearance: White powder
• Active Content: 95%
• Physical State: Solid
• pKa: 7.38±0.60

Synthetic Use

Downstream Synthesis Route 1

• 186581-53-3
• 108-24-7
• 117479-83-1
• 27200-12-0

• 117479-80-8

Reference: [1]Journal of the Chemical Society. Perkin transactions I,1988,p. 2567 - 2572

* For details of the synthesis route, please refer to the original source to ensure accuracy.