dCeMM2

• CAS: 296771-07-8
• Catalog Number: ACM-MG-296771078
• Category: Molecular Glues
• Molecular Weight: 370.82
• Molecular Formula: C16H11ClN6OS
• Description: dCeMM2 (Compound 2) is a glue degrader. dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex.
• Synonyms: 2-((5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-N-(5-chloropyridin-2-yl)acetamide
• IUPAC Name: N-(5-chloropyridin-2-yl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide
• SMILES: O=C(NC1=NC=C(Cl)C=C1)CSC2=NN=C3C(NC4=C3C=CC=C4)=N2
• InChI: InChI=1S/C16H11ClN6OS/c17-9-5-6-12(18-7-9)20-13(24)8-25-16-21-15-14(22-23-16)10-3-1-2-4-11(10)19-15/h1-7H,8H2,(H,18,20,24)(H,19,21,23)
• InChI Key: VFWVTIHYVUKNGR-UHFFFAOYSA-N
• Appearance: Light yellow to yellow soild
• Shipping: Generally, shipped at room temperature in continental US; may vary elsewhere.
• Storage Conditions: Store at 4 °C