Cerulenin

• CAS: 17397-89-6
• Catalog Number: ACM17397896
• Category: Inhibitors
• Molecular Weight: 223.27
• Molecular Formula: C12H17NO3
• Description: Cerulenin, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies.
• Synonyms: 2,3-Epoxy-4-oxo-7,10-dodecadienamide
• IUPAC Name: (2R,3S)-3-[(4E,7E)-nona-4,7-dienoyl]oxirane-2-carboxamide
• Canonical SMILES: C/C=C/C/C=C/CCC(=O)[C@@H]1[C@@H](O1)C(=O)N
• InChI: GVEZIHKRYBHEFX-NQQPLRFYSA-N
• InChI Key: InChI=1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6,10-11H,4,7-8H2,1H3,(H2,13,15)/b3-2+,6-5+/t10-,11-/m1/s1
• Melting Point: 93.5 °C
• Solubility: Soluble in DMSO (up to 10 mg/ml) or in ethanol (up to 10 mg/ml)
• Appearance: Off-white solid
• Storage: -20°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture).
• pKa: 15.19±0.40(Predicted)
• Shipping: Room temperature
• Source: Cephalosporium caeruleus
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
• Storage Temperature: -20 °C