Cephalotaxlen

• CAS: 24316-19-6
• Catalog Number: ACM24316196
• Category: Main Products
• Molecular Weight: 315.36
• Molecular Formula: C₁₈H₂₁NO₄
• Synonyms: CEPHALOTAXINE; Cephalotaxine
• IUPAC Name: cephalotaxine
• Boiling Point: 495.2ºC at 760 mmHg
• Flash Point: 253.3ºC
• Density: 1.38 g/cm³
• Appearance: White powder with faint yellow cast
• Exact Mass: 315.14700
• Hazard Statements: Xn: Harmful
• Packing Group: III
• Safety Description: 36

Case Study

Cephalotaxine for Inhibiting SARS-CoV-2 Membrane Fusion via Dual Targeting of Spike Protein and TMPRSS2

Gao J, et al. European Journal of Pharmacology, 2024, 983, 177012.

This study investigated the antiviral potential of cephalotaxine, a key metabolite of harringtonine, in blocking SARS-CoV-2 entry by targeting both the viral spike (S) protein and host TMPRSS2 protease. The experimental work focused on characterizing the dual inhibitory mechanism of cephalotaxine and its analog, 5'-de-O-methylharringtonine, through molecular binding and viral entry assays.
The compounds were evaluated using cell membrane chromatography, confirming their direct binding to both SARS-CoV-2 spike protein and TMPRSS2. Binding affinity was supported by molecular docking analyses, which revealed hydrogen bond formation at critical interaction residues involved in spike-ACE2 and TMPRSS2-nafamostat interfaces.
To assess functional activity, a pseudotyped virus assay was performed. Cephalotaxine exhibited dose-dependent inhibition of SARS-CoV-2 pseudovirus entry and membrane fusion, with enhanced efficacy correlating with increased TMPRSS2 expression levels in host cells. The inhibition of viral entry was monitored using luciferase-based reporter assays, confirming suppression of spike-mediated fusion. Toxicity profiles were evaluated via cytotoxicity assays on normal human cell lines, where cephalotaxine demonstrated low cytotoxicity and favorable safety margins.
These findings establish cephalotaxine as a dual-action membrane fusion inhibitor, offering a promising therapeutic avenue against SARS-CoV-2 and its variants.

Custom Q&A

What is the molecular formula of Cephalotaxlen?

The molecular formula of Cephalotaxlen is C18H21NO4.

What is the molecular weight of Cephalotaxlen?

The molecular weight of Cephalotaxlen is 315.4 g/mol.

What is the IUPAC name of Cephalotaxlen?

The IUPAC name of Cephalotaxlen is (2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-ol.

What is the InChI of Cephalotaxlen?

The InChI of Cephalotaxlen is InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3/t16-,17-,18+/m1/s1.

What is the InChIKey of Cephalotaxlen?

The InChIKey of Cephalotaxlen is YMNCVRSYJBNGLD-KURKYZTESA-N.

What is the CAS number of Cephalotaxlen?

The CAS number of Cephalotaxlen is 24316-19-6.

What is the Chemical Safety Laboratory Chemical Safety Summary (LCSS) Datasheet for Cephalotaxlen?

The LCSS Datasheet for Cephalotaxlen provides information on its chemical safety in laboratory settings.

What is the synonym of Cephalotaxlen?

The synonym of Cephalotaxlen is Omacetaxine.

How is Omacetaxine used medically?

Omacetaxine is used as a protein translation inhibitor for the treatment of chronic myeloid leukemia that is resistant to tyrosine kinase receptor antagonists.

Where is Cephalotaxlen found naturally?

Cephalotaxlen is found naturally in Cephalotaxus hainanensis, Cephalotaxus harringtonia, and other organisms.