CCT373566

• CAS: 2378853-66-6
• Catalog Number: ACM-MG-2378853666
• Category: Molecular Glues
• Molecular Weight: 547.00
• Molecular Formula: C26H29ClF2N6O3
• Description: CCT373566 is a potent and orally active molecular glue degrader of transcriptional repressor BCL6, with an IC50 of 2.2 nM. CCT373566 shows strong antiproliferative efficacy in vitro and reduction in tumor growth in vivo.
• IUPAC Name: (2S)-10-[[5-chloro-2-[(3R,5S)-3-hydroxy-5-methylpiperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-difluoro-7-methyl-2,4-dihydro-1H-[1,4]oxazepino[2,3-c]quinolin-6-one
• SMILES: O=C1N(C)C2=C(C=C(NC3=NC(N4C[C@H](O)C[C@H](C)C4)=NC=C3Cl)C=C2)C5=C1OCC(F)(F)[C@H](C6CC6)N5
• InChI: InChI=1S/C26H29ClF2N6O3/c1-13-7-16(36)11-35(10-13)25-30-9-18(27)23(33-25)31-15-5-6-19-17(8-15)20-21(24(37)34(19)2)38-12-26(28,29)22(32-20)14-3-4-14/h5-6,8-9,13-14,16,22,32,36H,3-4,7,10-12H2,1-2H3,(H,30,31,33)/t13-,16+,22-/m0/s1
• InChI Key: GSGDUDAFETZSPM-IATAILRESA-N
• Appearance: Light yellow to yellow soild
• Shipping: Generally, shipped at room temperature in continental US; may vary elsewhere.
• Storage Conditions: 4 °C, protect from light