Canertinib

• CAS: 267243-28-7
• Catalog Number: ACM267243287
• Category: Inhibitors
• Molecular Weight: 485.9
• Description: Canertinib (CI-1033;PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Canertinib is active against vaccinia virus respiratory infection in mice.
• Synonyms: N-[4-(3-Chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide
• InChI: InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29)
• InChI Key: OMZCMEYTWSXEPZ-UHFFFAOYSA-N
• Melting Point: 188-190 °C
• Complexity: 671
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 0
• Exact Mass: 485.1629955
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 2
• Monoisotopic Mass: 485.1629955
• Physical State: Powder
• Rotatable Bond Count: 9
• Topological Polar Surface Area: 88.6 Ų

Custom Q&A

What is the chemical formula of Canertinib?

The chemical formula of Canertinib is C27H32ClN5O5.

What are some synonyms for Canertinib?

Some synonyms for Canertinib include Canertinib(R&D), CS-385, Cediranib(AZD2171)N-(4-(3-chloro-4-fluorophenylamino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide, and CL177.

What is the melting point of Canertinib?

The melting point of Canertinib is 175-180°C.

How should Canertinib be stored?

Canertinib should be stored at -20°C in a freezer.

In what form does Canertinib exist?

Canertinib exists in a solid form.

What is the color of Canertinib?

Canertinib is a pale yellow in color.

What are the solubility characteristics of Canertinib?

Canertinib is soluble in DMSO and Methanol.

What are the primary uses of Canertinib?

Canertinib is used as an antineoplastic and as an irreversible pan-erbB tyrosine kinase inhibitor to treat cancer.

How does Canertinib function as an antineoplastic agent?

Canertinib functions as an antineoplastic agent by inhibiting pan-erbB tyrosine kinases, which are involved in cancer cell growth and proliferation.

Can Canertinib be classified as an API (Active Pharmaceutical Ingredient)?

Yes, Canertinib can be classified as an API.