Butanoic acid,4-(diethoxyphosphinyl)-,ethyl ester

• CAS: 2327-69-7
• Catalog Number: ACM2327697
• Category: Other Products
• Molecular Weight: 252.24
• Molecular Formula: C₁₀H₂₁O₅P
• Synonyms: NSC133820, ZINC01720859, Diethyl (3-carbethoxypropyl)phosphonate, Butyric acid, 4-diethylphosphono-, ethyl ester, Butanoic acid, 4-(diethoxyphosphinyl)-, ethyl ester, 2327-69-7
• IUPAC Name: ethyl 4-diethoxyphosphorylbutanoate
• InChI Key: FYESTJSRASJZOY-UHFFFAOYSA-N
• Boiling Point: 328.7ºC at 760mmHg
• Flash Point: 166.3ºC
• Density: 1.078g/cm³
• Appearance: clear light yellow liquid
• Exact Mass: 252.11300
• Hazard Statements: Xi: Irritant
• H-Bond Acceptor: 5
• H-Bond Donor: 0
• Safety Description: 37/39-26

Synthetic Use

Upstream Synthesis Route 1

• 2969-81-5
• 122-52-1

• 2327-69-7

Reference: [1]Wasielewski, Czeslaw; Antczak, Kazimierz
[Synthesis, 1981, # 7, p. 540 - 541]
[2]McConnell; Coover
[Journal of the American Chemical Society, 1956, vol. 78, p. 4450]
Sasin et al.
[Journal of the American Chemical Society, 1959, vol. 81, p. 4335][Journal of the American Chemical Society, 1959, vol. 81, p. 6275]
[3]Mel'nikov,N.N. et al.
[Journal of general chemistry of the USSR, 1961, vol. 31, p. 781 - 783][Zhurnal Obshchei Khimii, 1961, vol. 31, # 3, p. 849 - 852]

Downstream Synthesis Route 1

• 2327-69-7

• 13138-33-5

Reference: [1] The Journal of organic chemistry, 1972, vol. 37, # 26, p. 4396 - 4399

Downstream Synthesis Route 2

• 2327-69-7

• 13138-33-5

Reference: [1]Journal of Organic Chemistry,1972,vol. 37,p. 4396 - 4399

Downstream Synthesis Route 3

• 2327-69-7

• 38694-48-3

Reference: [1]Burgada, Ramon; Bailly, Theodorine; Lecouvey, Marc; Larue, Valery; Leroux, Yves
[European Journal of Organic Chemistry, 2001, # 2, p. 349 - 352]
[2]Hewitt, David G.; Teese, Murray W.
[Australian Journal of Chemistry, 1984, vol. 37, p. 1631 - 1642]
[3]Tsvetkov,E.N. et al.
[Journal of general chemistry of the USSR, 1975, vol. 45, p. 706 - 713][Zhurnal Obshchei Khimii, 1975, vol. 45, p. 716 - 724]
[4]Current Patent Assignee: MERCK & CO INC - WO2010/51206, 2010, A1
Location in patent: Page/Page column 79-80
[5]Courtens, Charlotte; Risseeuw, Martijn; Caljon, Guy; Maes, Louis; Cos, Paul; Martin, Anandi; Van Calenbergh, Serge
[Bioorganic and Medicinal Chemistry Letters, 2019, vol. 29, # 10, p. 1232 - 1235]

* For details of the synthesis route, please refer to the original source to ensure accuracy.