CAS
3034764-41-2 Purity
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3034764-41-2 Purity
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BRD4 degrader-2
CAS
3036530-43-2
Catalog Number
ACM-MG-3036530432
Category
Molecular Glues
Molecular Weight
657.18
Molecular Formula
C34H33ClN6O4S
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Specification
Description
BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells.
SMILES
ClC1=CC=C(C2=N[C@@H](CC(N3CCN(C(/C=C/C(C4=CC=C(OC)C=C4)=O)=O)CC3)=O)C5=NN=C(C)N5C6=C2C(C)=C(C)S6)C=C1
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Generally, shipped at room temperature in continental US; may vary elsewhere.
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