CAS
--- Purity
>99%
--- Purity
>99%
Shopping basket
BMS-986449
Catalog Number
ACM-MG-00005
Category
Molecular Glues
Molecular Weight
396.41
Molecular Formula
C21H21FN4O3
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- Product Description
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Specification
Description
BMS-986449 is a CELMoD molecular glue and an IKZF2/IKZF4 degrader. BMS-986449 targets the degradation of transcription factors Helios (IKZF2) and Eos (IKZF4) in regulatory T (Treg) cells. BMS-986449 redirects the E3 ubiquitin ligase Cereblon to induce the degradation of Helios and Eos, reprogramming Treg cells and enhancing antitumor immunity. BMS-986449 is promising for research of advanced solid tumors.
SMILES
NC1=NC(C2=C(F)C([C@@H](C)N([C@H]3CCC(NC3=O)=O)C4=O)=C4C=C2)=CC(C)=C1C
Shipping
Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions
Please store the product under the recommended conditions.
Please kindly note that our products are for research use only.
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