Bafilomycin a1

• CAS: 88899-55-2
• Catalog Number: ACM88899552
• Category: Inhibitors
• Molecular Weight: 622.83
• Molecular Formula: C₃₅H₅₈O₉
• Description: Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis.