Avadomide

• CAS: 1015474-32-4
• Catalog Number: ACM-MG-1015474324
• Category: Molecular Glues
• Molecular Weight: 286.29
• Molecular Formula: C14H14N4O3
• Description: Avadomide is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities.
• Synonyms: CC 122
• IUPAC Name: 3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione
• SMILES: O=C(C(N1C(C)=NC2=C(C(N)=CC=C2)C1=O)CC3)NC3=O
• InChI: InChI=1S/C14H14N4O3/c1-7-16-9-4-2-3-8(15)12(9)14(21)18(7)10-5-6-11(19)17-13(10)20/h2-4,10H,5-6,15H2,1H3,(H,17,19,20)
• InChI Key: RSNPAKAFCAAMBH-UHFFFAOYSA-N
• Appearance: White to gray solid
• EC Number: 876-404-3
• Shipping: Generally, shipped at room temperature in continental US; may vary elsewhere.
• Storage Conditions: Store at 4 °C