CAS
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AR Degrader-1
Catalog Number
ACM-MG-00004
Category
Molecular Glues
Molecular Weight
531.03
Molecular Formula
C24H27ClN6O4S
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Specification
Description
AR Degrader-1 (Compound ML 2-9) is a molecular glue androgen receptor (AR) monovalent degrader. AR Degrader-1 degrades AR through DCAF16 (E3 ligase) without obvious cytotoxicity in LNCaP prostate cancer cells.
SMILES
O=C(C1=NN=C(N2CCN(S(=O)(C=C)=O)CC2)C=C1)N[C@H]3CC[C@H](OC4=CC=C(C#N)C(Cl)=C4)CC3
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Generally, shipped at room temperature in continental US; may vary elsewhere.
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