Antitumor agent-100

• CAS: 2841750-32-9
• Catalog Number: ACM-MG-2841750329
• Category: Molecular Glues
• Molecular Weight: 311.77
• Molecular Formula: C17H14ClN3O
• Description: Antitumor Agent-100 (compound A6) is a molecular gel and apoptosis inducer targeting PDE3A-SLFN12 with an IC50 of 0.3 μM, demonstrating potent antitumor activity. This orally available agent binds to the PDE3A enzyme pocket, recruiting and stabilizing SLFN12 which disrupts protein translation and induces apoptosis.
• Synonyms: Compound A6
• IUPAC Name: 6-chloro-7-(4-methylphenyl)-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one
• SMILES: CC1=CC=C(C=C1)C2=C(C3=C(C=C2)N=C4NC(=O)CN4C3)Cl
• InChI: InChI=1S/C17H14ClN3O/c1-10-2-4-11(5-3-10)12-6-7-14-13(16(12)18)8-21-9-15(22)20-17(21)19-14/h2-7H,8-9H2,1H3,(H,19,20,22)
• InChI Key: OJBNZYSCDMZWHD-UHFFFAOYSA-N
• Shipping: Shipping with blue ice.
• Storage Conditions: Powder: Store at -20 °C for 3 years; In solvent: -80 °C for 1 year