4-Aminophenylboronic acid

• CAS: 89415-43-0
• Catalog Number: ACM89415430
• Category: Main Products
• Molecular Weight: 136.90
• Molecular Formula: C₆H₈BNO₂
• Synonyms: 4-Aminobenzeneboronic acid; 4-Boronoaniline; 4-Aminobenzeneboronicacidhydrochloride; 4-aminoyphenylboronic acid; 4-Aminophenylboronic acid
• IUPAC Name: (4-aminophenyl)boronic acid
• Boiling Point: 355ºC at 760 mmHg
• Melting Point: 62-66ºC
• Flash Point: 168.5ºC
• Density: 1.23
• Exact Mass: 137.06500
• Hazard Statements: Xi: Irritant;Xn: Harmful
• Safety Description: 26-36/37/39-36

Case Study

4-Aminophenylboronic Acid for the Construction of Antifouling Electrochemical Sulfide Sensors

Thiruppathi M, et al. Electrochimica Acta, 2024, 475, 143600.

4-Aminophenylboronic acid (4-APBA) was employed as a key reagent for the fabrication of a portable, disposable electrochemical sensor for sulfide detection. In this study, 4-APBA was electrochemically dimerized on the surface of functionalized multi-walled carbon nanotubes (f-CNTs), forming a robust sensing interface with strong electrocatalytic activity toward sulfide. The dimerized 4-APBA enhanced electron transfer and minimized surface fouling by elemental sulfur, a common challenge in sulfide detection. The modified electrode exhibited a linear detection range of 10 µM to 2 mM and a low detection limit of 2.3 µM, demonstrating high sensitivity and selectivity. Notably, the antifouling properties of the 4-APBA/f-CNT composite allowed for reliable sulfide analysis in serum samples without complex pretreatment. The sensor was successfully applied to assess sulfide levels in clinical samples, revealing significantly lower sulfide concentrations in diabetic patients compared to healthy individuals. Furthermore, the system differentiated cancer cells from normal ones based on intracellular sulfide concentration.

4-Aminophenylboronic Acid for the Construction of a Reduced Graphene Oxide-Based Electrochemical Glycan Sensor

Wang Q, et al. Biosensors and Bioelectronics, 2013, 50, 31-337.

4-Aminophenylboronic acid (APBA) was employed to construct a sensitive electrochemical sensor via incorporation into a reduced graphene oxide (rGO) matrix for sugar detection. The rGO/APBA composite was synthesized by adding 1 mL of a 10 mM APBA ethanol solution to 1 mL of a 0.5 mg/mL aqueous graphene oxide (GO) suspension. The mixture was stirred at 100 °C for 12 hours, facilitating in situ reduction of GO and covalent incorporation of APBA. The resulting black precipitate was collected by centrifugation at 14,000 rpm for 20 minutes, washed three times each with ethanol and water, and dried at 80 °C for 6 hours. This composite was then deposited onto glassy carbon electrodes for differential pulse voltammetry (DPV) analysis. The rGO/APBA-modified electrode demonstrated pH-dependent current responses and was capable of selectively detecting monosaccharides such as fructose, mannose, and glucose via the specific boronic acid-diol interaction

Custom Q&A

What is the molecular formula of 4-Aminophenylboronic acid?

The molecular formula of 4-Aminophenylboronic acid is C6H8BNO2.

What is the molecular weight of 4-Aminophenylboronic acid?

The molecular weight of 4-Aminophenylboronic acid is 136.95 g/mol.

What is the IUPAC name of 4-Aminophenylboronic acid?

The IUPAC name of 4-Aminophenylboronic acid is (4-aminophenyl)boronic acid.

What is the InChI of 4-Aminophenylboronic acid?

The InChI of 4-Aminophenylboronic acid is InChI=1S/C6H8BNO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,9-10H,8H2.

What is the InChIKey of 4-Aminophenylboronic acid?

The InChIKey of 4-Aminophenylboronic acid is MKPDAJWEBQRQCO-UHFFFAOYSA-N.

What is the canonical SMILES of 4-Aminophenylboronic acid?

The canonical SMILES of 4-Aminophenylboronic acid is B(C1=CC=C(C=C1)N)(O)O.

What is the CAS number of 4-Aminophenylboronic acid?

The CAS number of 4-Aminophenylboronic acid is 89415-43-0.

What is the European Community (EC) number of 4-Aminophenylboronic acid?

The European Community (EC) number of 4-Aminophenylboronic acid is 640-548-3.

Is 4-Aminophenylboronic acid a covalently-bonded unit?

Yes, 4-Aminophenylboronic acid is a covalently-bonded unit.