ALV2

• CAS: 2438124-95-7
• Catalog Number: ACM-MG-2438124957
• Category: Molecular Glues
• Molecular Weight: 523.97
• Molecular Formula: C26H26ClN5O5
• Description: ALV2 is a potent and selective Helios degrader. ALV2 binds CRBN, with an IC50 of 0.57 μM. Helios is the zinc-finger transcription factor that can maintain a stable Treg cell phenotype in the inflammatory tumor microenvironment.
• IUPAC Name: 1-(3-chloro-4-methylphenyl)-3-[2-[3-[[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxopyrrol-3-yl]amino]phenyl]propan-2-yl]urea
• SMILES: O=C(NC(C)(C1=CC=CC(NC2=CC(N(C(CC3)C(NC3=O)=O)C2=O)=O)=C1)C)NC4=CC=C(C)C(Cl)=C4
• InChI: InChI=1S/C26H26ClN5O5/c1-14-7-8-17(12-18(14)27)29-25(37)31-26(2,3)15-5-4-6-16(11-15)28-19-13-22(34)32(24(19)36)20-9-10-21(33)30-23(20)35/h4-8,11-13,20,28H,9-10H2,1-3H3,(H2,29,31,37)(H,30,33,35)
• InChI Key: YKFHBIMJVFQOQL-UHFFFAOYSA-N
• Appearance: White to yellow solid
• Shipping: Generally, shipped at room temperature in continental US; may vary elsewhere.
• Storage Conditions: Store at -20 °C