ABT-384

• CAS: 868623-40-9
• Catalog Number: ACM868623409
• Category: Inhibitors
• Molecular Weight: 493.58
• Molecular Formula: C25H34F3N5O2
• Description: ABT-384 is an 11β-hydroxysteroid dehydrogenase type 1 inhibitor.
• Synonyms: ABT-384; ABT 384; ABT384
• IUPAC Name: 4-[[2-methyl-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanoyl]amino]adamantane-1-carboxamide
• Canonical SMILES: O=C(C12CC3C(NC(C(N4CCN(C5=NC=C(C(F)(F)F)C=C5)CC4)(C)C)=O)C(C2)CC(C3)C1)N
• InChI: InChI=1S/C25H34F3N5O2/c1-23(2,33-7-5-32(6-8-33)19-4-3-18(14-30-19)25(26,27)28)22(35)31-20-16-9-15-10-17(20)13-24(11-15,12-16)21(29)34/h3-4,14-17,20H,5-13H2,1-2H3,(H2,29,34)(H,31,35)
• InChI Key: CLHMYBJIOZXCEX-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Biological Target: ABT-384 is a potent, selective 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor that exhibits high affinity (Ki 0.1-2.7 nM) against rodent, monkey, and human 11β-HSD1 and blocks regeneration of active cortisol.
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 60.84; H, 6.94; F, 11.55; N, 14.19; O, 6.48
• Exact Mass: 493.2665
• HS Tariff Code: 2934.99.9001
• In Vitro Activity: TBD
• In Vivo Activity: TBD
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).