6-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine

• CAS: 105655-01-4
• Catalog Number: ACM105655014
• Category: Bromine Series
• Molecular Weight: 250.52
• Molecular Formula: C8H9BrClNO
• Synonyms: 6-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine;6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride;6-Bromo-3,4-dihydro-2H-1,4-benzoxazine
• IUPAC Name: 6-bromo-3,4-dihydro-2H-1,4-benzoxazine
• SMILES: C1COC2=C(N1)C=C(C=C2)Br
• InChI Key: RWKBNMSHIJBNAO-UHFFFAOYSA-N
• Boiling Point: 296.364ºC at 760 mmHg
• Flash Point: 133.036ºC
• Density: 1.534 g/cm³
• Exact Mass: 212.97900
• H-Bond Acceptor: 2
• H-Bond Donor: 1

Synthetic Use

Upstream Synthesis Route 1

• 24036-52-0

• 105655-01-4

Reference: [1] Patent: WO2008/44022, 2008, A1, . Location in patent: Page/Page column 29

Upstream Synthesis Route 2

• 1235451-65-6

• 105655-01-4

Reference: [1] Patent: WO2011/130628, 2011, A1, . Location in patent: Page/Page column 227

Upstream Synthesis Route 3

• 40925-68-6
• 106-93-4

• 105655-01-4

Reference: [1] Heterocyclic Communications, 2012, vol. 18, # 3, p. 143 - 146
[2] Patent: WO2018/183633, 2018, A1, . Location in patent: Paragraph 0006; 0008; 0017;0106; 0107

Upstream Synthesis Route 4

• 188947-78-6

• 105655-01-4

Reference: [1]Journal of Medicinal Chemistry,1997,vol. 40,p. 1465 - 1474

Upstream Synthesis Route 5

• 24036-52-0

• 105655-01-4

Reference: [1]Patent: WO2008/44022,2008,A1 .Location in patent: Page/Page column 29

Downstream Synthesis Route 1

• 50-00-0
• 105655-01-4

• 188947-79-7

Reference: [1]Journal of Medicinal Chemistry,1997,vol. 40,p. 1465 - 1474
[2]Patent: US2019/47960,2019,A1 .Location in patent: Paragraph 0644; 0645; 0646; 0647
[3]Patent: US2019/47961,2019,A1 .Location in patent: Paragraph 0643-0644

* For details of the synthesis route, please refer to the original source to ensure accuracy.