(2-Aminoethoxy)diphenylborane

• CAS: 524-95-8
• Catalog Number: ACM524958
• Category: Other Products
• Molecular Weight: 225.1g/mol
• Molecular Formula: C14H16BNO
• Synonyms: 2,2-DIPHENYL-1,3,2-OXAZA-BOROLIDINE INTERNAL SALT;2-APB;2-AMINOETHYL DIPHENYL BORATE;2-AMINOETHYL DIPHENYLBORINATE;(2-AMINOETHOXY)DIPHENYLBORANE;2-AMINOETHOXYDIPHENYLBORATE;BETA-AMINOETHYL DIPHENYLBORINATE;DIPHENYLBORIC ACID 2-AMINOETHYL ESTER
• IUPAC Name: 2-diphenylboranyloxyethanamine
• Canonical SMILES: B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN
• InChI: InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
• InChI Key: BLZVCIGGICSWIG-UHFFFAOYSA-N
• Melting Point: 193.0 °C
• Application: (2-Aminoethoxy)diphenylborane serves as a versatile tool in biochemical research and cellular modulation. It is primarily utilized for the densitometric determination of flavonoids and acts as an activator of transient receptor potential (TRP) channels. This compound plays a crucial role in manipulating the intracellular release of calcium ions, which is vital for various cellular processes. Additionally, it is employed in the preparation of apoptotic inducers and acts as a membrane-permeable inhibitor of store-operated calcium entry (SOCE). As a modulator of intracellular calcium levels, it inhibits calcium release triggered by inositol-1,4,5-triphosphate (IP3) and affects various TRP channels, including inhibiting TRPC6 and TRPM8 while activating TRPV1, TRPV2, and TRPV3. Furthermore, it is involved in inhibiting calcium transients and differentiation in primary mouse brown adipocytes and even extends its influence to improving cognitive functions in rats by altering TRPM2 protein levels.
• Complexity: 182
• Covalently-Bonded Unit Count: 1
• EC Number: 208-366-5
• Exact Mass: 225.132494g/mol
• Formal Charge: 0
• H-Bond Acceptor: 2
• H-Bond Donor: 1
• Heavy Atom Count: 17
• Monoisotopic Mass: 225.132494g/mol
• NSC Number: 17107
• Rotatable Bond Count: 5
• UNII: E4ES684O93