(1R,3S,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

• CAS: 423165-07-5
• Catalog Number: ACM423165075
• Category: Other Products
• Molecular Weight: 234.34
• Molecular Formula: C₁₃H₂₂N₄
• Synonyms: (3-Exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl] -8-Azabicyclo[3.2.1]octane;Des[1-(4,4-difluorocyclohexanecarboxamido)-1-phenylpropyl] Maraviroc;UK 408027;(1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane;8-Azabicyclo[3,2,1]octane3-[3-methyl-5-(1-methlethyl)-4H-1,2,4-triazol-4-yl]-,(3-exo)-;Maraviroc Intermediate 2;Maraviroc interMediate(Tropinone);(3-exo)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octane
• Melting Point: 117 ºC
• Density: 1.31

Synthetic Use

Upstream Synthesis Route 1

• 423165-13-3

• 423165-07-5

Reference: [1] Patent: WO2008/63600, 2008, A2, . Location in patent: Page/Page column 11-12; 28

Upstream Synthesis Route 2

• 76272-34-9

• 423165-07-5

Reference: [1] Patent: US2011/251192, 2011, A1,

Upstream Synthesis Route 3

• 542-05-2

• 423165-07-5

Reference: [1] Patent: US2011/251192, 2011, A1,

Upstream Synthesis Route 4

• 423165-13-3

• 423165-07-5

Reference: [1]Patent: WO2008/63600,2008,A2 .Location in patent: Page/Page column 11-12; 28

Downstream Synthesis Route 1

• 423165-07-5
• 135865-78-0

• 376348-70-8

Reference: [1]Tetrahedron Letters,2005,vol. 46,p. 5005 - 5007
[2]European Journal of Organic Chemistry,2018,vol. 2018,p. 1821 - 1832

Downstream Synthesis Route 2

• 423165-07-5
• 376348-78-6

• 376348-65-1

Reference: [1]Journal of the American Chemical Society,2007,vol. 129,p. 15398 - 15404
[2]Patent: US2019/248782,2019,A1 .Location in patent: Paragraph 0030

* For details of the synthesis route, please refer to the original source to ensure accuracy.