Togashi D1, Otsuka I, Borsali R, Takeda K, Enomoto K, Kawaguchi S, Narumi A.
Biomacromolecules. 2014 Dec 8;15(12):4509-19. doi: 10.1021/bm501314f. Epub 2014 Nov 6.We now describe the synthesis of a new family of oligosaccharide-conjugated functional molecules, which act as chain transfer agents (CTAs) for the reversible addition-fragmentation chain transfer (RAFT) polymerization. The synthesis was started from the catalyst-free direct N-glycosyl reaction of 5-azidopentylamine onto maltopentaose (Mal5) in dry methanol at room temperature and subsequent N-protected reaction with acetic anhydride, producing a stable oligosaccharide-building block, such as Mal5 with an azidopentyl group (Mal5-N3). Read More