PLLA

Product Description

As a specialized supplier of plastics and related materials, Alfa Chemistry offers a comprehensive selection of high-performance biodegradable polymers, including poly(L-lactide) (PLLA). This material is a widely recognized biodegradable and bio-based polymer with outstanding biocompatibility, controlled degradation, and robust mechanical properties, making it ideal for numerous high-value applications across medical, pharmaceutical, and packaging sectors.

• Materials: PLLA (poly(L-lactide))
• Appearance: White or yellowish granules
• Chemical formula: (C₆H₈O₄)_n

Product Specifications

Item	Quality Index
Intrinsic Viscosity	0.3-5 dL/g
Molecular Weight Distribution	≤2.0
Specific Rotation	-155° to -160° (Solvent: Chloroform, Conc: 0.01g/ml)
Moisture Content	≤0.5%
Ash Content	≤0.5%
Monomer Residue	≤2%
Solvent Residue	≤1,000ppm
Tin Residue	≤150ppm
Total Heavy Metals (as Pb)	≤10ppm

Catalog	Product	Intrinsic Viscosity
PL-PLLA-A001	PLLA Granule	0.3-0.5 dL/g
PL-PLLA-A002	PLLA Granule	0.5-0.7 dL/g
PL-PLLA-A003	PLLA Granule	0.7-1.0 dL/g
PL-PLLA-A004	PLLA Granule	0.9-1.2 dL/g
PL-PLLA-A005	PLLA Granule	1.5-2.0 dL/g
PL-PLLA-A006	PLLA Granule	2.0-2.7 dL/g
PL-PLLA-A007	PLLA Granule	2.7-3.6 dL/g
PL-PLLA-A008	PLLA Granule	3.2-4.3 dL/g
PL-PLLA-A009	PLLA Granule	5.6-7.5 dL/g

Key Features and Benefits

• Excellent Biocompatibility: PLLA exhibits outstanding biocompatibility, making it ideal for in vivo applications.
• Controlled Biodegradability: One of PLLA's key advantages is its predictable degradation rate, which can be tailored by adjusting molecular weight, crystallinity, and processing methods.
• High Mechanical Strength: PLLA possesses excellent tensile strength and stiffness, comparable to traditional petroleum-based polymers.
• Optical Clarity and Processability: PLLA can be fabricated into optically clear films and fibers, which are highly desirable for packaging and biomedical uses.

Application Areas

PLLA's versatility allows for its application across several critical sectors:

• Medical Field

• Facial Rejuvenation: PLLA has gained significant traction in medical aesthetics, particularly as an injectable filler. It works by stimulating fibroblasts to produce collagen, leading to improved skin texture and smoothness.
• Orthopedics and Implants: This polymer is instrumental in creating absorbable medical devices such such as fixation plates and sutures. For instance, PLLA cervical spine fixation plates have demonstrated stable mechanical properties and no significant changes observed between one to five months post-surgery, greatly assisting in bone graft healing and tissue reconstruction.
• Tissue Engineering: PLLA functions as a vital scaffold material, promoting cell growth and facilitating tissue regeneration. While its inherent brittleness and slower degradation rate can pose limitations, these can be overcome through material modification.

• Packaging Industry

Embracing the shift towards sustainable solutions, PLLA is a preferred material for environmentally friendly packaging. Its biodegradability makes it ideal for products like food packaging films and agricultural mulch films. These applications not only contribute to reducing environmental pollution but also meet specific performance requirements for various packaging needs.

• Other Diverse Applications

Beyond the core medical and packaging sectors, PLLA is also integrated into:

• Drug sustained-release systems: PLLA microspheres, for example, are used to enhance drug bioavailability and therapeutic efficacy through controlled release.
• Cosmetics
• Biosensors

Processing Techniques

PLLA can be fabricated using several advanced processing methods, including:

• Injection Molding – for high-precision medical implants and packaging components.
• Electrospinning – for fabricating nanofiber scaffolds in tissue engineering.

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