PLGA

Product Description

As a professional supplier of plastics and related services, our company provides a broad range of high-performance polymers, including poly(D,L-lactide-co-glycolide) (PLGA). PLGA is a synthetic copolymer formed by the random ring-opening copolymerization of lactide (LA) and glycolide (GA). The resulting material is an amorphous, aliphatic polyester with excellent biocompatibility, biodegradability, and tunable degradation rates. Due to these unique properties, PLGA has become a preferred material in controlled drug delivery, surgical sutures, tissue engineering scaffolds, and other advanced medical technologies.

• Materials: PLGA (poly(D,L-lactide-co-glycolide))
• Appearance: White or yellowish granules
• Chemical formula: (C₆H₈O₄)_n(C₄H₄O₄)_m

Product Specifications

Item	Quality Index
Intrinsic Viscosity	0.2-2.5 dL/g
Viscosity-Average Molecular Weight	1-400,000
Number-Average Molecular Weight	1-1,000,000
Glass Transition Temperature	40-60℃
Residual Monomer	< 1%
Residual Solvent	< 0.05%
Heavy Metals	< 10 ppm
Density	1.2-1.3 g/cm³
Sulfate Ash	< 0.05%

Catalog	Product	LA/GA	Intrinsic Viscosity
PL-PLGA-A001	PLGA Granule	90/10	0.2-0.4 dL/g
PL-PLGA-A002	PLGA Granule	90/10	0.4-0.7 dL/g
PL-PLGA-A003	PLGA Granule	90/10	0.70-1.00 dL/g
PL-PLGA-A004	PLGA Granule	90/10	1.00-1.40 dL/g
PL-PLGA-A005	PLGA Granule	90/10	1.40-1.80 dL/g
PL-PLGA-A006	PLGA Granule	90/10	1.80-2.20 dL/g
PL-PLGA-A007	PLGA Granule	90/10	2.20-2.50 dL/g
PL-PLGA-A008	PLGA Granule	75/25	0.20-0.40 dL/g
PL-PLGA-A009	PLGA Granule	75/25	0.40-0.70 dL/g
PL-PLGA-A010	PLGA Granule	75/25	0.70-1.00 dL/g
PL-PLGA-A011	PLGA Granule	75/25	1.00-1.40 dL/g
PL-PLGA-A012	PLGA Granule	75/25	1.40-1.80 dL/g
PL-PLGA-A013	PLGA Granule	75/25	1.80-2.20 dL/g
PL-PLGA-A014	PLGA Granule	75/25	2.20-2.50 dL/g
PL-PLGA-A015	PLGA Granule	50/50	0.20-0.40 dL/g
PL-PLGA-A016	PLGA Granule	50/50	0.40-0.70 dL/g
PL-PLGA-A017	PLGA Granule	50/50	0.70-1.00 dL/g

Key Features and Benefits

• Biocompatibility: PLGA is well tolerated by biological systems and does not provoke significant immune or toxic responses, making it suitable for use in vivo.
• Biodegradability: The polymer hydrolyzes into lactic acid and glycolic acid, both naturally metabolized by the human body, ensuring safe and complete bioresorption.
• Controlled Degradation: By varying the LA/GA monomer ratio, the degradation rate of PLGA can be precisely controlled. A higher glycolide content results in faster degradation, while a higher lactide content provides slower degradation and increased hydrophobicity.
• Mechanical Versatility: PLGA offers good mechanical strength and processability, allowing it to be fabricated into films, fibers, scaffolds, or microspheres.

Application Areas

The unique attributes of PLGA make it an indispensable material across a broad spectrum of advanced biomedical and pharmaceutical applications:

• Controlled Drug Delivery Systems: PLGA is the material of choice for developing advanced drug delivery systems, including microspheres, nanospheres, and liposomes for sustained and targeted drug release. Its tunable degradation rate enables precise control over the release of pharmaceuticals, vaccines, and biologics, improving therapeutic outcomes and reducing dosing frequency.
• Tissue Engineering Scaffolds: In the rapidly evolving field of tissue engineering, PLGA serves as an ideal scaffold material for the regeneration and repair of various tissues, such as cartilage, bone, and skin. Its biocompatibility, biodegradability, and ability to form porous structures provide an excellent environment for cell proliferation and tissue integration.
• Advanced Medical Devices: PLGA is widely utilized in the manufacturing of cutting-edge medical devices. Prominent examples include absorbable surgical sutures, which eliminate the need for removal; anti-adhesion barriers designed to prevent unwanted tissue scarring after surgery; and internal fixation devices for bone fractures that gradually resorb as the bone heals.
• Biomedical Research: Beyond direct clinical applications, PLGA is a critical tool in biomedical research, where it is used to develop novel carriers and devices for investigating biological processes, such as advanced drug delivery platforms and biosensors.

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