PDLLA

Product Description

As a professional supplier of plastics and related services, Alfa Chemistry offers a broad range of high-performance biodegradable materials, including poly(D,L-lactide) (PDLLA). This versatile aliphatic polyester, chemically known as poly(D,L-lactide), is synthesized through the random ring-opening polymerization of D-lactide and L-lactide monomers. Due to its racemic composition, PDLLA possesses an amorphous, non-crystalline structure, which significantly enhances its biodegradability and resorption rate, making it ideal for short-term biomedical and therapeutic applications.

• Materials: PDLLA (poly(D,L-lactide))
• Appearance: White or yellowish granules
• Chemical formula: (C₆H₈O₄)_n

Product Specifications

Item	Quality Index
Intrinsic Viscosity	0.18-4 dL/g
Viscosity-Average Molecular Weight	1-1,000,000
Number-Average Molecular Weight	1-1,000,000
Glass Transition Temperature	50-60℃
Residual Monomer	< 1%
Residual Solvent	< 0.05%
Heavy Metals	< 10 ppm
Density	1.2-1.3 g/cm³
Sulfate Ash	< 0.05%

Catalog	Product	Intrinsic Viscosity
PL-PDLLA-A001	PDLLA Granule	0.18-0.30 dL/g
PL-PDLLA-A002	PDLLA Granule	0.30-0.50 dL/g
PL-PDLLA-A003	PDLLA Granule	0.50-0.70 dL/g
PL-PDLLA-A004	PDLLA Granule	0.70-1.00 dL/g
PL-PDLLA-A005	PDLLA Granule	1.00-1.50 dL/g
PL-PDLLA-A006	PDLLA Granule	1.50-2.00 dL/g
PL-PDLLA-A007	PDLLA Granule	2.00-2.50 dL/g
PL-PDLLA-A008	PDLLA Granule	2.50-3.00 dL/g
PL-PDLLA-A009	PDLLA Granule	3.00-4.00 dL/g

Key Features and Benefits

• Non-toxic and Non-irritating: Ensuring safety for sensitive biological applications.
• Biodegradable and Absorbable: It naturally breaks down in the body, eliminating the need for removal.
• High Strength: It offers robust mechanical integrity for various structural uses.
• Good Plasticity and Easy Processability: It can be readily molded and shaped using techniques like injection molding and electrospinning.
• Controlled Degradation: It typically degrades within 2 to 12 months, aligning perfectly with short-term implant requirements.

Application Areas

The exceptional properties of PDLLA, particularly its excellent biocompatibility and tunable degradation, have led to its widespread adoption in numerous critical applications:

• Drug Delivery Systems: PDLLA is extensively used as a matrix for encapsulating pharmaceutical agents, forming microspheres and nanoparticles for controlled and sustained drug release. It can be used as an excipient in injectable microcapsules, microspheres, and implants designed for sustained release.
• Tissue Engineering: Its ability to form porous scaffolds makes PDLLA an ideal material for supporting cell growth and facilitating tissue regeneration, including applications in bone fixation and tissue repair.
• Surgical and Medical Devices: PDLLA is a preferred material for surgical sutures, absorbable implants and clamps, and components in orthopedic fixation.
• Regenerative Medicine: Innovative uses include the development of artificial skin and artificial blood vessels.
• Ophthalmic Applications: It finds utility in specialized ophthalmic implant materials, such as those for retinal applications.

Processing and Storage Guidelines

PDLLA can be efficiently processed using common methods such as injection molding and melt spinning, offering flexibility in manufacturing.

Given its biodegradable nature, proper storage of PDLLA products is critical to preserve their quality and integrity:

• Avoid Degrading Agents: PDLLA is sensitive to moisture, acids, alkalis, and alcohols. Therefore, it must not come into contact with water or these chemical reagents during storage.
• Sealed, Dry, and Low-Temperature Storage: For optimal preservation, PDLLA should be stored sealed, dry, and at a low temperature, ideally frozen at -20°C in a refrigerator.
• Controlled Humidity During Use: To prevent moisture absorption by the product, the ambient air humidity during use should be less than 35%.

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