PD184352

Description: PD184352 / CI-1040 is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5.

• Catalog: OFC212631793
• CAS: 212631-79-3
• Category: Fluorinated APIs
• Synonyms: CI-1040
• Purity: >98%

• IUPAC Name: 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
• InChI: InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
• InChI Key: GFMMXOIFOQCCGU-UHFFFAOYSA-N
• Isomeric SMILES: C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
• EC Number: 695-548-6

• Molecular Formula: C17H14ClF2IN2O2
• Molecular Weight: 478.66
• Appearance: White to off-white solid powder

• XLogP3-AA: 5.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 477.97566 g/mol
• Monoisotopic Mass: 477.97566 g/mol
• Topological Polar Surface Area: 50.4Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 472