ODM-203

Description: ODM-203 is a selective inhibitor of FGFR and VEGFR with ic50s of 11 nM,16 nM,6 nM, 35 nM,26 nM,9 nM,5 nM for recombinant FGFR1, FGFR2, FGFR3,FGFR4, VEGFR1, VEGFR2 and VEGFR3, respectively.

• Catalog: OFC1430723355
• CAS: 1430723-35-5
• Category: Fluorinated APIs
• Synonyms: N-[3-(2,4-difluorophenyl)-5-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]phenyl]cyclopropanesulfonamide
• Purity: >98%

• IUPAC Name: N-[3-(2,4-difluorophenyl)-5-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]phenyl]cyclopropanesulfonamide
• InChI: InChI=1S/C26H21F2N5O2S/c1-32-14-18(13-30-32)16-2-7-26-25(10-16)29-15-33(26)21-9-17(23-6-3-19(27)11-24(23)28)8-20(12-21)31-36(34,35)22-4-5-22/h2-3,6-15,22,31H,4-5H2,1H3
• InChI Key: ZJFCBQXPTQSTCZ-UHFFFAOYSA-N
• Isomeric SMILES: CN1C=C(C=N1)C2=CC3=C(C=C2)N(C=N3)C4=CC(=CC(=C4)NS(=O)(=O)C5CC5)C6=C(C=C(C=C6)F)F

• Molecular Formula: C26H21F2N5O2S
• Molecular Weight: 505.55
• Appearance: White to off-white solid powder

• XLogP3-AA: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 505.13840243 g/mol
• Monoisotopic Mass: 505.13840243 g/mol
• Topological Polar Surface Area: 90.2Ų
• Heavy Atom Count: 36
• Formal Charge: 0
• Complexity: 886