Mirdametinib

Description: PD0325901 / Mirdametinib is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.

• Catalog: OFC391210109
• CAS: 391210-10-9
• Category: Fluorinated APIs
• Synonyms: PD-0325901
• Purity: >98%

• IUPAC Name: N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
• InChI: InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
• InChI Key: SUDAHWBOROXANE-SECBINFHSA-N
• Isomeric SMILES: C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O
• EC Number: 687-152-7

• Molecular Formula: C16H14F3IN2O4
• Molecular Weight: 482.19
• Appearance: White to off-white solid powder

• XLogP3-AA: 3
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 481.99504 g/mol
• Monoisotopic Mass: 481.99504 g/mol
• Topological Polar Surface Area: 90.8Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 465