4-Methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile

• Catalog: OFC1628317189
• CAS: 1628317-18-9
• Category: Fluorinated Nitriles
• Synonyms: MI-463
• Purity: 97%
• MDL Number: MFCD28506301

• Molecular Formula: C24H23F3N6S
• Molecular Weight: 484.54
• Molar Refractivity: 131.44

• Bioavailability Score: 0.55
• Egan: 1.0
• Ghose: None
• Lipinski: 0.0
• Muegge: 1.0
• Veber: 0.0
• Consensus LogP: 4.91
• MLogP: 2.78
• SILICOS-IT: 6.27
• WLogP: 6.07
• XLogP3: 5.91
• iLogP: 3.5
• BBB Permeant: No
• CYP1A2 Inhibitor: No
• CYP2C19 Inhibitor: Yes
• CYP2C9 Inhibitor: Yes
• CYP2D6 Inhibitor: Yes
• CYP3A4 Inhibitor: Yes
• GI Absorption: Low
• LogKp: -5.06 cm/s
• P-gp Substrate: Yes
• Fraction Csp3: 0.38

• GHS Pictogram: GHS07
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P305+P351+P338