Filanesib

Description: Filanesib / ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing.

• Catalog: OFC885060093
• CAS: 885060-09-3
• Category: Fluorinated APIs
• Synonyms: ARRY-520
• Purity: >95%

• IUPAC Name: (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide
• InChI: InChI=1S/C20H22F2N4O2S/c1-25(28-2)19(27)26-20(11-6-12-23,14-7-4-3-5-8-14)29-18(24-26)16-13-15(21)9-10-17(16)22/h3-5,7-10,13H,6,11-12,23H2,1-2H3/t20-/m0/s1
• InChI Key: LLXISKGBWFTGEI-FQEVSTJZSA-N
• Isomeric SMILES: CN(C(=O)N1[C@](SC(=N1)C2=C(C=CC(=C2)F)F)(CCCN)C3=CC=CC=C3)OC

• Molecular Formula: C20H22F2N4O2S
• Molecular Weight: 420.48
• Appearance: White solid powder

• XLogP3-AA: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 420.14315345 g/mol
• Monoisotopic Mass: 420.14315345 g/mol
• Topological Polar Surface Area: 96.5Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 605