Dilmapimod

Description: Dilmapimod / SB-681323 / GW-681323 inhibits TNF-alpha production and is a potent p38 MAPK inhibitor that potentially suppresses inflammation in COPD.

• Catalog: OFC444606182
• CAS: 444606-18-2
• Category: Fluorinated APIs
• Synonyms: SB-681323
• Purity: >98%

• IUPAC Name: 8-(2,6-difluorophenyl)-2-(1,3-dihydroxypropan-2-ylamino)-4-(4-fluoro-2-methylphenyl)pyrido[2,3-d]pyrimidin-7-one
• InChI: InChI=1S/C23H19F3N4O3/c1-12-9-13(24)5-6-15(12)20-16-7-8-19(33)30(21-17(25)3-2-4-18(21)26)22(16)29-23(28-20)27-14(10-31)11-32/h2-9,14,31-32H,10-11H2,1H3,(H,27,28,29)
• InChI Key: ORVNHOYNEHYKJG-UHFFFAOYSA-N
• Isomeric SMILES: CC1=C(C=CC(=C1)F)C2=C3C=CC(=O)N(C3=NC(=N2)NC(CO)CO)C4=C(C=CC=C4F)F

• Molecular Formula: C23H19F3N4O3
• Molecular Weight: 456.42
• Appearance: White to off-white solid powder

• XLogP3-AA: 3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 6
• Exact Mass: 456.14092497 g/mol
• Monoisotopic Mass: 456.14092497 g/mol
• Topological Polar Surface Area: 98.6Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 702