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The fluorinated carboxilic acids are strong acids due to the strong electronegativity of the fluorine atom. They have good heat resistance and chemical stability, do not react with general reducing agents and oxidizing agents in aqueous solution. And as important fluorinated building blocks, they are widely used in the synthesis of organic fluorides. For example, fluorinated carboxilic acids can undergo reductive amination reactions to obtain fluorinated amines. They can also synthetize fluorinated aldehydes or fluorinated alcohols through hydrogenation. Fluorinated carboxilic acids can also undergo various conversion reactions to obtain a series of carboxilic acid derivatives. At present, fluorinated carboxilic acids and derivatives have received extensive attention, and their synthesis have become a hot spot in organic chemistry.
There are various methods for the synthesis of fluorinated carboxylic acids and derivatives. The following are some selected methods for the preparation of fluorinated carboxylic acids and derivatives.
Fig.1 Synthesis of fluorinated carboxilic acids through one-pot method
Fig.2 Synthesis of fluorinated carboxilic acids through Mannich-type reaction
Alfa Chemistry can offer various fluorinated carboxilic acids and derivatives building blocks such as fluorinated acyl chlorides, fluorinated acid anhydrides, fluorinated nitriles and fluorinated acrylates and methacrylates. You can click on our product list for a detailed view. At the same time, we also offer product customization according to customer's detailed requirements. If you are interested in our products, please feel free to contact us. We will be happy to provide you with support and services.
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