What is the molecular formula of Methoxyl-d3-amine Hydrochloride?
The molecular formula is CH6ClNO.
What are the synonyms for Methoxyl-d3-amine Hydrochloride?
The synonyms are Methoxyl-d3-amine Hydrochloride, O-(Trideuteriomethyl)hydroxylamine;hydrochloride, Methoxyamine-d3 (Hydrochloride), and Methoxyl-d3-amine HCl.
What is the molecular weight of Methoxyl-d3-amine Hydrochloride?
The molecular weight is 86.53 g/mol.
What is the parent compound of Methoxyl-d3-amine Hydrochloride?
The parent compound is Methoxy-d3-amine.
Are there any component compounds of Methoxyl-d3-amine Hydrochloride?
Yes, Methoxyl-d3-amine Hydrochloride contains Methoxy-d3-amine and Hydrochloric Acid as component compounds.
When was Methoxyl-d3-amine Hydrochloride created?
Methoxyl-d3-amine Hydrochloride was created on February 1, 2011.
When was Methoxyl-d3-amine Hydrochloride last modified?
Methoxyl-d3-amine Hydrochloride was last modified on October 21, 2023.
What is the IUPAC Name of Methoxyl-d3-amine Hydrochloride?
The IUPAC Name is O-(trideuteriomethyl)hydroxylamine;hydrochloride.
What is the InChIKey of Methoxyl-d3-amine Hydrochloride?
The InChIKey is XNXVOSBNFZWHBV-NIIDSAIPSA-N.
What is the CAS number of Methoxyl-d3-amine Hydrochloride?
The CAS number is 110220-55-8.
Methoxyl-d3-Amine Hydrochloride Used for the Synthesis of Deuterium-Labeled Cefuroxime
Dawei Liang. Et al. Mendeleev communications, 2015, 4(25), 252-253.
The deuterium-labeled internal standard drug cefuroxime was synthesized using methoxy-d3-amine hydrochloride through a five-step procedure, which can be used in a wide range of pharmacological studies of cefuroxime. Synthesis procedure of cefuroxime-d1 · A 66% yield of d3-(2Z)-2-(2-Furyl)-2-(methoxyimino)acetic acid 3 was obtained by reacting 2-(2-furyl)-2-oxoacetic acid 2 with methoxyl-d3-amine hydrochloride in ethanol under reflux conditions for 6 hours. · The resulting compound 3 was then converted to acid chloride 4 using oxalyl chloride in the presence of DMF, and without purification, acid chloride 4 was used in the acylation of 7-ACA in dichloromethane with DIPEA, yielding amide 5 in 67% yield. · Hydrolysis of the ester group in 5 was achieved by treatment with NaOH at temperatures below -20°C for approximately 5 hours. · Further experimentation showed that acid 6 could undergo intramolecular esterification to form lactone 7 when neutralization was carried out at room temperature. By reducing the workup temperature to below -20°C, a 73% yield of hydroxy acid 6 was obtained, thus improving the overall efficiency of the reaction.
※ Please kindly note that our products are for research use only.