Meprednisone

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Catalog Number
ACM1247423
Product Name
Meprednisone
Structure
Structure
CAS
1247-42-3
Category
Inhibitors
Description
Meprednisone is a glucocorticoid and a methylated derivative of prednisone.Target: Glucocorticoid ReceptorMeprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL .
Synonyms
BETAPAR; betalone; betapred; bitanisone; deltisonab; betanisona; methylprednisone;
IUPAC Name
(8S,9S,10R,13S,14S,16S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
Molecular Weight
372.45
Molecular Formula
C22H28O5
Canonical SMILES
CC1CC2C3CCC4=CC(=O)C=CC4(C3C(=O)CC2(C1(C(=O)CO)O)C)C
InChI Key
PIDANAQULIKBQS-RNUIGHNZSA-N
Boiling Point
574.4ºC at 760mmHg
Melting Point
204-206ºC
Flash Point
315.2ºC
Density
1.28g/cm³
Appearance
white solid
Storage
4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light).
EC Number
214-996-1
Exact Mass
372.19400
Shipping
Can be shipped at room temperature, where not in use may vary.
Please kindly note that our products are for research use only.

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