Lasofoxifene

• Catalog Number: ACM180916169
• Product Name: Lasofoxifene
• CAS: 180916-16-9
• Category: Heterocyclic Organic Compound
• Synonyms: CP-336,156;(5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]tetralin-2-ol;(5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol;(5R-cis)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol;Lasofoxifene;(5R,6S)-;Lasofoxifene Base
• Molecular Weight: 413.55
• Molecular Formula: C₂₈H₃₁NO₂
• Melting Point: 110-113°C

Custom Q&A

What is the molecular formula of Lasofoxifene?

The molecular formula of Lasofoxifene is C28H31NO2.

What is the molecular weight of Lasofoxifene?

The molecular weight of Lasofoxifene is 413.5 g/mol.

How is Lasofoxifene described in terms of its chemical structure and properties?

Lasofoxifene is described as a member of the class of tetralins with specific substitutions and roles as an antineoplastic agent, cardioprotective agent, estrogen receptor agonist, estrogen receptor antagonist, and bone density conservation agent.

What is the role of Lasofoxifene as a drug?

Lasofoxifene is a non-steroidal, naphthalene-derived, third-generation selective estrogen receptor modulator (SERM) with potential antineoplastic and anti-osteoporotic activities.

How does Lasofoxifene act upon administration?

Upon oral administration, Lasofoxifene selectively binds to estrogen receptors alpha and beta with high affinity, mimicking the effects of endogenous estradiol with varying agonist and antagonist effects in estrogen receptor-expressing tissues.

What was Lasofoxifene initially developed for?

Lasofoxifene was initially developed by Pfizer as Oporia for the treatment of postmenopausal osteoporosis and vaginal atrophy.

How was Lasofoxifene eventually approved?

Fablyn, a version of Lasofoxifene, was developed as a result of a research collaboration between Pfizer and Ligand Pharmaceuticals, gaining approval by the European Commission in March 2009.

What potential use of Lasofoxifene is discussed in the NCI Thesaurus?

Lasofoxifene may potentially be useful in the treatment of tumors that have acquired resistance to other estrogen receptor-targeting agents, due to its binding to certain mutant forms of the estrogen receptor.

What are some identifiers associated with Lasofoxifene?

Some identifiers associated with Lasofoxifene include its CAS number (180916-16-9), UNII (337G83N988), and ChEMBL ID (CHEMBL328190).

What is the chemical structure representation of Lasofoxifene in both canonical and isomeric SMILES?

The canonical SMILES representation is C1CCN(C1)CCOC2=CC=C(C=C2)C3C(CCC4=C3C=CC(=C4)O)C5=CC=CC=C5. The isomeric SMILES representation is C1CCN(C1)CCOC2=CC=C(C=C2)[C@H]3[C@H](CCC4=C3C=CC(=C4)O)C5=CC=CC=C5.