Dzhekieva L1, Rocaboy M, Kerff F, Charlier P, Sauvage E, Pratt RF.
Biochemistry. 2010 Aug 3;49(30):6411-9. doi: 10.1021/bi100757c.The Actinomadura R39 DD-peptidase is a bacterial low molecular weight class C penicillin-binding protein. It has previously been shown to catalyze hydrolysis and aminolysis of small D-alanyl-D-alanine terminating peptides, especially those with a side chain that mimics the amino terminus of the stem peptide precursor to the bacterial cell wall. This paper describes the synthesis of (D-alpha-aminopimelylamino)-D-1-ethylboronic acid, designed to be a peptidoglycan-mimetic transition state analogue inhibitor of the R39 DD-peptidase. Read More