What is the molecular formula of clodronic acid?
The molecular formula of clodronic acid is CH4Cl2O6P2.
What is the molecular weight of clodronic acid?
The molecular weight of clodronic acid is 244.89 g/mol.
What are the synonyms of clodronic acid?
The synonyms of clodronic acid include Clodronate, 10596-23-3, (Dichloromethylene)diphosphonic acid, and Clodronsaeure.
What is the role of clodronic acid?
Clodronic acid has a role as a bone density conservation agent and an antineoplastic agent. It inhibits bone resorption and soft tissue calcification and is used in the treatment of severe hypercalcaemia associated with malignancy, as well as in the management of osteolytic lesions and bone pain associated with skeletal metastases.
How does clodronic acid exert its cytotoxic effect on osteoclasts?
Although the exact mechanism is not fully elucidated, clodronic acid is metabolized intracellularly to a toxic beta-gamma-methylene analog of adenosine triphosphate (ATP), AppCCl2p. The ATP analog competitively inhibits ADP/ATP translocase, thereby interfering with mitochondrial membrane potential and cellular energy metabolism. This may cause osteoclast apoptosis and, eventually, inhibiting osteoclast-mediated bone resorption.
Is clodronic acid FDA approved?
No, clodronic acid is not FDA approved. However, it is approved in Canada.
What generation of bisphosphonates does clodronic acid belong to?
Clodronic acid is a first-generation bisphosphonate.
What is the IUPAC name of clodronic acid?
The IUPAC name of clodronic acid is [dichloro(phosphono)methyl]phosphonic acid.
What is the Canonical SMILES of clodronic acid?
The Canonical SMILES of clodronic acid is C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl.
What is the CAS number of clodronic acid?
The CAS number of clodronic acid is 10596-23-3.