Chaves JD1, Tunes LG2, de J Franco CH1, Francisco TM3, Corrêa CC1, Murta SM2, Monte-Neto RL2, Silva H4, Fontes AP1, de Almeida MV5.
Eur J Med Chem. 2016 Oct 24. pii: S0223-5234(16)30914-X. doi: 10.1016/j.ejmech.2016.10.052. [Epub ahead of print]The current anticancer and antileishmanial drug arsenal presents several limitations concerning their specificity, efficacy, costs and the emergence of drug-resistant cells lines, which encourages the urgent need to search for new alternatives. Inspired by the fact that gold(I)-based compounds are promising antitumoral and antileishmanial drug candidates, we synthesized novel gold(I) complexes containing phosphine and 5-phenyl-1,3,4-oxadiazole-2-thione and evaluated their anticancer and antileishmanial activities. Read More