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online inquiryBlokhina S, Sharapova A, Ol'khovich M, et al.
Thermochimica Acta, 2015, 622: 97-102.
Temperature dependences of saturated vapor pressure for crystalline phases of 2-ethyl-4-pyridinecarbothioamide (ethionamide) and two parent compounds 2- and 4-pyridinecarbothioamide isomers were measured by the transpiration method. The results were used to determine the standard molar enthalpies, entropies and Gibbs energies of sublimation at T = 298.15 K. HYBOT descriptors application has shown an increase in the donor–acceptor ability of the molecules of the studied compounds to form hydrogen bonds to result in their crystal lattice energy growth. Read MoreVolkova T V, Blokhina S V, Sharapova A V, et al.
Thermochimica Acta, 2016, 640: 1-7.
The solubility of antituberculosis drug ethionamide and structural analogues in buffer solutions, octanol and hexane within the temperature range from (293.15–313.15) K was measured using the shake-flack method. All the compounds studied appeared to have the solubility neither more than 10-3 mol fraction in aqueous solutions. At that the solubility in buffer pH 7.4 is lower than that in pH 2.0 which is determined by the ionization state. Read MoreProducts
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