JTT-501

Name: JTT-501
SKU: ACM170861639
Rating: 5 (1 reviews)

CAS

170861-63-9

Catalog Number

ACM170861639

Category

Main Products

Molecular Weight

392.4

Molecular Formula

C22H20N2O5

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Specification

Appearance

Solid

The Oral Antidiabetic Drug JTT-501 Demonstrates Specific Pharmacological Characteristics

Shibata, Tsutomu, et al. European Journal of Pharmacology, 1999, 364(2-3), 211-219.

The compound JTT-501 is a unique isoxazolidinedione derivative which stands apart from thiazolidinediones like pioglitazone and troglitazone because of its structure. The study examined how JTT-501 affected insulin sensitivity and functioned within rodent models of diabetes.
Key Findings
· The compound JTT-501 demonstrated enhanced insulin-stimulated differentiation of 3T3-L1 fibroblasts with an effective concentration of 110 nM. JTT-501 showed activation properties on peroxisome proliferator-activated (PPA) γ and α receptors at EC5-fold concentrations of 0.28 and 5.4 μM.
· JTT-501 successfully reduced hyperglycemia and hyperinsulinemia while lowering hypertriglyceridemia levels and strengthened insulin-triggered glucose oxidation in adipose tissues of KK-Ay mice which represent non-insulin-dependent diabetes mellitus.
· JTT-501 demonstrated efficacy in the non-insulin-dependent diabetes mellitus model using Zucker diabetic fatty (ZDF) rats yet failed to show effectiveness in the insulin-dependent diabetes model of streptozotocin-induced diabetic mice.
· The findings demonstrate that JTT-501 increases insulin responsiveness in peripheral tissues and decreases hyperglycemia, hyperinsulinemia, and hypertriglyceridemia in non-insulin dependent diabetes mellitus models. JTT-501 exhibits a unique ability to reduce triglyceride levels which sets it apart from thiazolidinediones. JTT-501 shows potential as an antidiabetic medication for patients with non-insulin-dependent diabetes who experience insulin resistance.

The Impact of JTT-501 on PDE3B Gene Expression in Obese Diabetic KKAy Mice

Tang, Yan, et al. European journal of endocrinology, 2001, 145(1), 93-99.

Phosphodiesterase (PDE) 3B serves as a primary enzyme that drives insulin's anti-lipolytic action within adipocytes. The activation of PDE3B results in decreased free fatty acid (FFA) output and high serum FFA levels lead to insulin resistance. This study identified the reduced expression of PDE3B gene specifically in adipose tissue from KKAy mice. Then, researchers examined how JTT-501, which is a peroxisome proliferator-activated receptor (PPAR)γ ligand, affected PDE3B gene expression.
Key Findings
· Research revealed that mRNA levels of PDE3B together with protein counts and membrane-bound PDE activity in KKAy mice adipose tissues reduced to 47%, 57% and 51% compared to C57BL/6J control mice values.
· In untreated KKAy mice JTT-501 elevated levels of PDE3B mRNA by 2.2-fold and protein levels by 1.6-fold and membrane-bound PDE activity by 1.7-fold. In KKAy mice liver tissue PDE3B gene expression showed no alteration and treatment with JTT-501 did not produce any effects. JTT-501 lowered elevated serum levels of insulin, glucose, FFA, and triglycerides in KKAy mice.
· The adipose tissues of KKAy mice exhibited specific downregulation of PDE3B gene expression. The administration of JTT-501 restored lowered gene expression levels and led to better insulin resistance while also decreasing elevated serum FFA levels.

What is the molecular formula of JTT-501?

The molecular formula of JTT-501 is C22H20N2O5.

What are the synonyms of JTT-501?

The synonyms of JTT-501 are Reglitazar, 170861-63-9, Reglitazar [INN], and P9UTN18JVV.

What is the molecular weight of JTT-501?

The molecular weight of JTT-501 is 392.4 g/mol.

When was JTT-501 created?

JTT-501 was created on June 24, 2005.

Who is developing JTT-501?

JTT-501 is being developed by Pfizer for the treatment of diabetes.

What is the structure of JTT-501?

The structure of JTT-501 can be viewed at the following link: https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=154000&t=l

What is the IUPAC name of JTT-501?

The IUPAC name of JTT-501 is 4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione.

What is the InChI of JTT-501?

The InChI of JTT-501 is InChI=1S/C22H20N2O5/c1-14-19(23-21(28-14)16-5-3-2-4-6-16)11-12-27-17-9-7-15(8-10-17)13-18-20(25)24-29-22(18)26/h2-10,18H,11-13H2,1H3,(H,24,25).

What is the InChIKey of JTT-501?

The InChIKey of JTT-501 is QBQLYIISSRXYKL-UHFFFAOYSA-N.

What is the CAS number of JTT-501?

The CAS number of JTT-501 is 170861-63-9.