Aluminum chlorohydrate

• CAS: 1327-41-9
• Catalog Number: ACM1327419
• Category: Main Products
• Molecular Weight: 79.44
• Molecular Formula: AlClH₂O
• Synonyms: Aluminum hydroxychloride
• Appearance: Yellow solid
• Assay: 0.99
• Packaging: 1 kg
• Stability: Stable. Incompatible with many metals.

Case Study

Aluminum Chlorohydrate Coagulant for the Determination and Removal of Pharmaceuticals and Total Organic Carbon

Kuc J, et al. Molecules, 2022, 27(17), 5740.

Aluminum chlorohydrate (ACH) was used as a coagulant to remove total organic carbon (TOC) and erythromycin (ERY), fluoxetine (FLX), amoxicillin (AMO), colistin (COL), ethinyl estradiol (EE) and diclofenac (DIC) from surface water by coagulation. The study found that under the optimal coagulation process conditions, the concentrations of TOC, ERY, FLX, AMO, COL, EE and DIC in surface water samples treated with ACH were reduced by 88.7%, 36.4%, 24.7%, 29.0%, 25.5%, 35.4% and 30.4%, respectively.
Experimental methods
The experiments were conducted using 600 mL beakers equipped with magnetic stirrers that allowed for adjustable mixing speeds. For each trial, 500 mL of spiked river water was poured into the beaker, followed by the addition of a specified dosage of ACH and adjustments made to reach the desired pH level. The pH corrections for the treated water were achieved with a 15% solution of NaOH or H2SO4. The water was then stirred for a predetermined duration. After this period, stirring was halted, and the samples were allowed to settle for 30 minutes to enable the precipitation of sludge. Turbidity and total suspended solids (TSS) were assessed using unfiltered samples, while other parameters were measured on water that had been filtered through a 0.45 μm syringe filter. Prior to RP-HPLC-ESI-MS/MS analysis, the samples were also filtered through a 0.22 μm syringe filter. The concentration of total organic carbon (TOC) was analyzed to evaluate the effectiveness of TOC removal in each experiment.

Effect of Antiperspirant Aluminum Chloride on Antibiotic Resistance of Staphylococcus Epidermidis

Aras, Ayse, et al. Microorganisms, 2023, 11(4), 948.

Aluminum chlorohydrate (ACH) is an inorganic salt composed of complex basic aluminum chloride and is widely used as an antiperspirant. This work studied the effect of aluminum chlorohydrate on antibiotic resistance of Staphylococcus epidermidis, a normal human axillary flora.
Experimental methods and results
· A 40 μL volume of the bacterial suspension (adjusted to 10^8-10^9 cfu mL-1) was introduced into 3.96 mL of LB medium containing aluminum chlorohydrate at a concentration of 300 mg/L. Following incubation at 37 °C for 18-24 hours, 40 μL of the bacterial culture was transferred to another 3.96 mL of fresh LB with the same aluminum chlorohydrate concentration for further incubation. This process was repeated continuously for a span of 30 days. On the 10th and 30th days, 100 μL of the bacterial samples exposed to the aluminum chlorohydrate were plated onto MHA plates supplemented with 0.5 μg mL-1 oxacillin and 4 μg mL-1 ciprofloxacin.
· Alongside the observed ciprofloxacin resistance, there was a noticeable increase in the expression of the norA, norB/C, gyrA, gyrB, parC, and parE genes. Furthermore, all test bacteria in the group that was solely subcultured in the medium exhibited oxacillin resistance, indicating that phenotypic resistance may not be linked to chemical exposure based on these findings. The heightened expression of the mecA gene in certain test bacteria, which developed resistance to oxacillin after exposure, compared to control groups, suggests a potential association between the observed resistance and aluminum chlorohydrate exposure.

Aluminum chlorohydrate on estrogen receptor signaling

Gorgogietas, Vyron A., et al. Journal of molecular biochemistry 7.1 (2018): 1.

Aluminum salts are widely used as active antiperspirants in underarm cosmetics. Aluminum in the form of aluminum chlorohydrate (ACH) leads to increased estrogen receptor α (ERα) protein levels in ERα-positive MCF-7 cells. This effect is accompanied by a modest activation of estrogen response element (ERE)-driven reporter gene expression and a 20%-50% increase in the expression of certain estrogen-responsive, ERE-independent genes. The results suggest that the effects of aluminum on estrogen receptor protein levels and subcellular localization may affect receptor-mediated effects and, therefore, interference of aluminum with estrogen signaling.
Cells grown on coverslips were incubated with 200 nM CMX for 2 h at 37 °C in DMEM without phenol red, supplemented with 10% charcoal-inactivated serum, washed with phosphate-buffered saline (PBS) in the presence or absence of 10^-9 M E2, 10^-4 M aluminum chlorohydrate, fixed in methanol at -20 °C for 10 min, transferred to acetone (-20 °C) for 2 min, and air-dried briefly. Control cells were treated with vehicle.

Study on decolorization of silk dye bath effluent by aluminum chlorohydrate

Verma, Akshaya K., Puspendu Bhunia, and Rajesh R. Dash. Industrial & engineering chemistry research 51.25 (2012): 8646-8651.

The decolorization of silk dye bath effluent was carried out using analytical grade magnesium chloride (MCl) as coagulant aid and without guar gum (GG) as coagulant, technical grade polyaluminium chloride (PACl) and aluminium chlorohydrate (ACH) as coagulants. A higher decolorization efficiency of 97% was observed for MCl at a very high dosage of 1800 mg L. However, ACH was found to be the best coagulant considering purity, dosage, decolorization efficiency and quantity and quality of sludge production, with a decolorization efficiency of 91% being obtained with only a dosage of 100 mg L. To achieve this high decolorization efficiency, the dosage of PACl was found to be about 50% higher than that of ACH. ACH was effective in decolorizing at very low dosage and with minimal sludge generation, indicating that ACH is an effective coagulant for decolorizing silk dyeing wastewater.
The optimal pH and coagulant dosage required for effective color removal were determined by conducting a dye pot test. 1-liter beakers containing 500 mL of wastewater were used for coagulation experiments. H2SO4 was added to each beaker to adjust the pH. A chemical coagulant such as aluminum chlorohydrate was added and mixed for 3 min at a rapid stirring of 80 rpm. The solution was then slowly flocculated and mixed at 30 rpm for 15 min. After settling for 30 min, the supernatant on the top of the beaker was removed for analysis.

Custom Q&A

What is the molecular formula of aluminum chlorohydrate?

The molecular formula of aluminum chlorohydrate is Al2ClH9O7.

What are some synonyms for aluminum chlorohydrate?

Some synonyms for aluminum chlorohydrate include Alchlordrate, Phosphonorm, Oristar alch, Sumalchlor 50, HYPERDROL, and Takibine 1500.

What is the InChI of aluminum chlorohydrate?

The InChI of aluminum chlorohydrate is InChI=1S/2Al.ClH.7H2O/h;;1H;7*1H2/q2*+3;;;;;;;;/p-6.

What is the CAS number of aluminum chlorohydrate?

The CAS number of aluminum chlorohydrate is 12359-72-7.

What is the molecular weight of aluminum chlorohydrate?

The molecular weight of aluminum chlorohydrate is 210.48 g/mol.

How many hydrogen bond donor counts does aluminum chlorohydrate have?

Aluminum chlorohydrate has 7 hydrogen bond donor counts.

How many hydrogen bond acceptor counts does aluminum chlorohydrate have?

Aluminum chlorohydrate has 8 hydrogen bond acceptor counts.

What is the topological polar surface area of aluminum chlorohydrate?

The topological polar surface area of aluminum chlorohydrate is 7Ų.

How many heavy atoms are in aluminum chlorohydrate?

There are 10 heavy atoms in aluminum chlorohydrate.

Is the compound canonicalized?

Yes, the compound aluminum chlorohydrate is canonicalized.