Zschaler J1, Arnhold J2.
Prostaglandins Leukot Essent Fatty Acids. 2016 Apr;107:12-21. doi: 10.1016/j.plefa.2016.02.001. Epub 2016 Feb 17.Human neutrophil 5-lipoxygenase (5-LOX) oxidizes arachidonic acid (AA) to 5S-hydro(pero)xy-6E,8Z,11Z, 14Z-eicosatetraenoic acid (5-H(p)ETE) and leukotriene (LT)A4, which is further converted to the chemoattractant LTB4. These cells contain also the heme enzyme myeloperoxidase (MPO) producing several potent oxidants such as hypochlorous acid (HOCl). Previously, it was shown that MPO-metabolites influence 5-LOX product formation. Read More