Gamache RF1, Waldmann C2, Murphy JM2.
Org Lett. 2016 Sep 16;18(18):4522-5. doi: 10.1021/acs.orglett.6b02125. Epub 2016 Aug 29.A regiospecific method for the oxidative fluorination of aryl stannanes using tetrabutylammonium triphenyldifluorosilicate (TBAT) and copper(II) triflate is described. This reaction is robust, uses readily available reagents, and proceeds via a stepwise protocol under mild conditions (60 °C, 3.2 h). Broad functional group tolerance, including arenes containing protic and nucleophilic groups, is demonstrated.