Siddiqui NA1, Billa N2, Roberts CJ3, Asantewaa Osei Y4.
Pharmaceutics. 2016 Oct 8;8(4). pii: E30.Boronic acids have been widely investigated for their potential use as glucose sensors in glucose responsive polymeric insulin delivery systems. Interactions between cyclic diols and boronic acids, anchored to polymeric delivery systems, may result in swelling of the delivery system, releasing the drug. In this study, 4-formylphenylboronic acid conjugated chitosan was formulated into insulin containing nanoparticles via polyelectrolyte complexation. Read More