Sikora A1, Zielonka J, Lopez M, Joseph J, Kalyanaraman B.
Free Radic Biol Med. 2009 Nov 15;47(10):1401-7. doi: 10.1016/j.freeradbiomed.2009.08.006. Epub 2009 Aug 14.In this study, we show that boronates, a class of synthetic organic compounds, react rapidly and stoichiometrically with peroxynitrite (ONOO(-)) to form stable hydroxy derivatives as major products. Using a stopped-flow kinetic technique, we measured the second-order rate constants for the reaction with ONOO(-), hypochlorous acid (HOCl), and hydrogen peroxide (H(2)O(2)) and found that ONOO(-) reacts with 4-acetylphenylboronic acid nearly a million times (k=1. Read More